RNAi Controls
Genscript Corporation EGFR/HER1 hFc Chimera Human
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands The epidermal growth factor receptor is a member of the ErbB family of receptors a subfamily of four closely related receptor tyrosine kinases EGFR HER2/neu Her 3 and Her 4 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Genscript Corporation CD160 Fc Chimera Human
CD160 is a glycosylphosphatidylinositol-anchored Ig domain protein that is expressed on almost all intestinal intraepithelial lymphocytes (IELs) T (gamma delta T) cells NK (natural killer) cells and a minor subset of CD4 and CD8 T cells In terms of function work has centered on the role of CD160 in enhancing NK or CD8 T cell activation Such effects have been attributed to the ability of CD160 to bind classical and nonclassical MHC class I molecules although with apparent low affinity requiring clustering of MHC class I molecules or overexpression of CD160 or MHC class I for detection of the interaction
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
Genscript Corporation EGFR/HER1 hFc Chimera Human
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands The epidermal growth factor receptor is a member of the ErbB family of receptors a subfamily of four closely related receptor tyrosine kinases EGFR HER2/neu Her 3 and Her 4 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Genscript Corporation CD27/TNFRSF7 hFc Chimera Cyno
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD96/TACTILE mFc Chimera Huma
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
Genscript Corporation CD52 hFc Chimera Human
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation CD47 hFc Chimera Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
HORIZON DISCOVERY BIOSCIENCES LIMITED SMARTVECTOR INDUCIBLE NON-TARG
NC1122059 SMARTVECTOR INDUCIBLE NON-TARG
STA PHARMACEUTICAL US LLC DNA A(Bz) amidite | 1 g | CAS 98796-53-3 | MDL MFCD00036314
DNA A(Bz) amidite is a Amidite reagent (Subcategory: Adenine Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 98796-53-3
- MDL: MFCD00036314
- InChIKey: GGDNKEQZFSTIMJ-AKWFTNRHSA-N
- Molecular Weight: 857.948761998
- Molecular Formula: C47H52N7O7P
- Purity: ≥99%
- Container Type: 30 mL Glass (28-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 50.1 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1C[C@H](N2C3=C(N=C2)C(NC(C4=CC=CC=C4)=O)=NC=N3)O[C@@H]1COC(C5=CC=C(C=C5)OC)(C6=CC=C(C=C6)OC)C7=CC=CC=C7)OCCC#N)C(C)C)C
Genscript Corporation CD28H/IGPR-1 hFc Chimera Huma
CD28H is constitutively expressed on all naive T cells Repetitive antigenic exposure however induces a complete loss of CD28H on many T cells and CD28H negative T cells have a phenotype of terminal differentiation and senescence After extensive screening in a receptor array a B7-like molecule B7 homologue 5 (B7-H5) was identified as a specific ligand for CD28H
Genscript Corporation CD161 hFc Chimera Human
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment
Genscript Corporation CD200 R1/CRTR2 hFc Chimera Hu
CD200Fc a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region regulates immune responses following engagement of a cell surface receptor CD200R expressed on cells of the myeloid and T cell lineage A recent report focused attention on a family of CD200Rs but concluded that only one member used CD200 as its ligand