RNAi Controls
Genscript Corporation EGFR/HER1 hFc Chimera Human
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands The epidermal growth factor receptor is a member of the ErbB family of receptors a subfamily of four closely related receptor tyrosine kinases EGFR HER2/neu Her 3 and Her 4 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Genscript Corporation TNFRSF12A/TWEAKR hFc Chimera
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer in addition PPAR signaling pathway insulin signaling pathway mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A
Genscript Corporation CD40/TNFRSF5 hFc Chimera Huma
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects CD40 molecule is a potential target for cancer immunotherapy There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
STA PHARMACEUTICAL US LLC DNA A(Bz) amidite | 10 g | CAS 98796-53-3 | MDL MFCD00036314
DNA A(Bz) amidite is a Amidite reagent (Subcategory: Adenine Series) sold by WuXi TIDES. Offered in 10 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 98796-53-3
- MDL: MFCD00036314
- InChIKey: GGDNKEQZFSTIMJ-AKWFTNRHSA-N
- Molecular Weight: 857.948761998
- Molecular Formula: C47H52N7O7P
- Purity: ≥99%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1C[C@H](N2C3=C(N=C2)C(NC(C4=CC=CC=C4)=O)=NC=N3)O[C@@H]1COC(C5=CC=C(C=C5)OC)(C6=CC=C(C=C6)OC)C7=CC=CC=C7)OCCC#N)C(C)C)C
Genscript Corporation CD160 hFc Chimera Mouse
CD160 (also Natural killer cell receptor BY55) is a 27 30 kDa member of the Ig superfamily In human it is expressed principally on nonmyeloid hematopoietic cells CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation Exists as a GPI-anchored and as a transmembrane form each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells
Genscript Corporation VEGF R3/FLT4 hFc Chimera Huma
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1 -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors VEGF-R1 -R2 and -R3 were highly expressed in CRC cells and stromal vessels VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD27/TNFRSF7 hFc Chimera Huma
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD27/TNFRSF7 hFc Chimera Cyno
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD28H/IGPR-1 hFc Chimera Huma
CD28H is constitutively expressed on all naive T cells Repetitive antigenic exposure however induces a complete loss of CD28H on many T cells and CD28H negative T cells have a phenotype of terminal differentiation and senescence After extensive screening in a receptor array a B7-like molecule B7 homologue 5 (B7-H5) was identified as a specific ligand for CD28H
Genscript Corporation TROP-2/TACSTD2 hFc Chimera Hu
Trop-2 also known as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene Mutations of this gene result in gelatinous drop-like corneal dystrophy an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness
Genscript Corporation TNFRSF12A/TWEAKR hFc Chimera
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer in addition PPAR signaling pathway insulin signaling pathway mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A
Genscript Corporation CD47 hFc Chimera Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers